Description
Title: Inflammasome Components’ Role in Kidney Disease
Abstract: Multiprotein complexes called inflammasomes play a significant part in the innate immune response. Interleukin-1 and -18 mature as a result of caspase-1 activation and canonical inflammasome activation. These cytokines can have an effect by activating receptors both locally in a specific tissue and systemically. Inflammasome involvement in pyroptosis, fibrosis, and inflammation has been demonstrated in animal models of kidney diseases. Investigations have focused on the canonical mechanisms related to the inflammasome component nucleotide-binding domain-like receptor family pyrin domain containing 3 (NLRP3). However, it is now more obvious than ever that kidney disease also involves other inflammasome components. Furthermore, it is becoming clear that a variety of molecular partners interact with inflammasome components in kidney diseases. With a focus on the interactions between inflammasome components and redox signaling, endoplasmic reticulum stress, and mitochondrial function, this review sheds light on these hot topics in research. For both acute kidney injury and chronic kidney disease, we present our findings separately. This review allows for a comparison of findings from those complementary research specialties because we strictly separated the results into preclinical and clinical data. It also reveals that there are still many unanswered questions, particularly in the field of clinical acute kidney injury inflammasome research. Inflammasome component alterations in human kidney disease appear to be significantly influenced by patient comorbidities and treatments, as well.
Keywords: acute kidney injury; chronic kidney disease; kidney transplantation; inflammasome; redox signalling; endoplasmic reticulum stress; interleukin-18; interleukin-1β; NLRP3; AIM2; caspase-8
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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