Description
Title: Integrins’ Function in Vascular Remodeling and Smooth Muscle Cell Plasticity: From Expression to Therapeutic Implications
Abstract: SMCs, which are found in the media layer of blood vessels, are essential for preserving vascular homeostasis. SMCs exhibit a high degree of plasticity in response to vascular injury, changing from a “contractile” to a “synthetic” phenotype, and are crucial in the pathophysiology of diseases like atherosclerosis and restenosis. Integrins are cell surface receptors that participate in binding between cells and interactions with extracellular matrix. Integrins initiate intracellular signaling and control a number of SMC functions, such as proliferation, migration, and phenotypic switching, by binding to elements of the extracellular matrix. Although antibodies and synthetic peptides have been successfully used to target integrins to limit atherosclerosis and restenosis, no such drug has yet to be commercialized. To enable the creation of integrin-based interventions to combat atherosclerosis and restenosis, a thorough understanding of how integrins modulate SMC biology is imperative. The role of integrins in regulating the functional characteristics of SMCs and their implications for vascular pathology are highlighted in this article.
Keywords: integrins; smooth muscle cell; phenotype switching; neointimal hyperplasia; restenosis; extracellular matrix; fibronectin
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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