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Title: The COVID-19 Pandemic from a Biotechnological Perspective: Precise Diagnostics and Inevitable Vaccine Paradigms
Abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is to blame for the ongoing public health crisis around the world. With the fluctuating emergence of its new variants, it is more commonly known as coronavirus disease 2019 (COVID-19), and the pandemic threat is still present. A high rate of human mortality and disruption to socioeconomic well-being have resulted from COVID-19, which can range in severity from asymptomatic to severe acute respiratory distress syndrome (ARDS). The international scientific community has been conducting research on a war footing to reduce the extremely pathogenic COVID-19 through diagnosis, treatment, and immunization in order to restore pre-pandemic normalcy. Numerous laboratory-based and point-of-care (POC) approaches have been developed since the first report of COVID-19 viral infection for diagnosing and comprehending the status of the outbreak. One of the most popular and quickly developed COVID-19 detection methods is the RT-PCR-based viral nucleic acid test (NAT). Notably, the development of secure, focused vaccines and vaccine injections (shots) that can lower the morbidity and mortality linked to COVID-19 is required given its current forbidding status. The best and last chance to stop the COVID-19 pandemic would be massive and accelerated vaccination campaigns. Emerging biotechnologies and their multidisciplinary approaches have sped up the understanding of molecular details as well as the development of a variety of diagnostics and potential vaccine candidates, which are essential to combating the highly contagious COVID-19 virus. This has been true since the SARS-CoV-2 virus outbreak. Following their introduction through emergency use authorization, several vaccine candidates that have finished phase III clinical studies are said to be effective at immunizing against COVID-19 (EUA). To combat the dangerous variants that are anticipated to appear over time, it is essential to optimize the kind of vaccine candidates and its route of delivery that works best to control viral spread. In conclusion, the knowledge gained from this review will help in the creation of the best diagnostic tools and COVID-19 vaccines.
Keywords: ARDS; coronavirus; detection methods; SARS-CoV-2; COVID-19; CRISPR; vaccine; nucleic acid test (NAT)
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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