Description
Title: B-Cell-Based Immunotherapy: A Hopeful New Option
Abstract: Over the past ten years, there have been significant conceptual shifts in the immunotherapy field. Monoclonal antibodies, cancer vaccines, tumor-infecting viruses, cytokines, adjuvants, and adoptive immunotherapy using autologous T cells with chimeric antigen receptors (CARs) that can bind cancer-specific antigens are a few examples of immunotherapy. Although significant progress has been made in the field of T-cell immunotherapy, only a small percentage of patients (20%) experience long-lasting advantages from this form of therapy, which highlights the urgent need to focus on other immune cells. It has been demonstrated that B cells function in tumor tissue in both pro- and anti-tumorigenic ways. We clarified the dual nature of B cells in the tumor microenvironment in this review. We also covered the various elements influencing the biology and operation of B cells in tumors. We discussed B-cell-based immunotherapies, their clinical applications, and difficulties in the third section. These current studies serve as a platform for conducting upcoming mechanistic studies that will enable us to fully utilize B cells in immunotherapy.
Keywords: B cells; IgM; IgG; B cell receptor; Breg
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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