Description
Title: Leishmania metabolic pathways: a source of relevant drug targets and powerful drug candidates
Abstract: Tropical disease called leishmaniasis is brought on by the protozoan parasite Leishmania, which is spread by infected female sandflies. Chemotherapy is the mainstay of leishmaniasis treatment at the moment. The currently available leishmaniasis medications are expensive, toxic, have a variety of side effects, and have restrictions on how they should be administered. The potency of anti-leishmanial medications has been significantly diminished by the quick emergence of drug resistance. A novel anti-leishmanial drug with high potency, low cost, acceptable toxicity, and good pharmacokinetics features is urgently needed as a result. Drug repurposing is a useful strategy for accelerating the development of effective anti-leishmanial by pointing to new drug targets in less time, having low costs, and having low risk due to the availability of preclinical data. Leishmania species grow and proliferate during different stages of their life cycle in large part due to the parasite’s metabolic pathways. Based on available genomics/proteomics data, known drugs that were used to treat other diseases could target Leishmania-specific proteins via known pathways (sterol biosynthetic pathway, purine salvage pathway, glycolysis, GPI biosynthesis, hypusine, polyamine biosynthesis), leading to the discovery of new, promising anti-leishmanial therapeutics. The current review discusses various metabolic pathways used by the Leishmania parasite as well as some potential future leishmaniasis treatments that effectively target these pathways.
Keywords: Leishmania; human pathogen; targeting metabolic pathways; repurposed drugs; new anti-leishmanials
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
Plagiarism Report: Turnitin Plagiarism Report will be less than 10%
Restriction: Only one author may purchase a single paper. The paper will then indicate that it is out of stock.
What will I get after the purchase?
A turnitin plagiarism report of less than 10% in a pdf file and a full research paper in a word document.
In case you have any questions related to this research paper, please feel free to call/ WhatsApp on +919726999915
Reviews
There are no reviews yet.