Research Paper on Techniques for Increasing Bioavailability of Poorly Aqueous Soluble Drugs and Therapeutics

Description

Title: Techniques for Increasing Bioavailability of Poorly Aqueous Soluble Drugs and Therapeutics

Abstract: Pharmacoactive molecules’ low water solubility restricts their pharmacological potential, but the solubility parameter cannot be compromised, so various strategies are used to increase their bioavailability. Low solubility pharmaceutically active molecules carry a higher risk of failure for drug development and innovation. Their solubility has a significant impact on pharmacokinetics, pharmacodynamics, and a number of other factors, including drug distribution, protein binding, and absorption. Oral dosage forms account for more than 50% of all pharmaceutical dosage forms, and the drug molecule should be water-soluble. Solubility and bioavailability are essential components for the drug molecule’s effective therapeutic activity at the target site. According to the screening programs used by the pharmaceutical industry, about 40% of new chemical entities (NCEs) encounter various challenges during the formulation and development phases. These drugs exhibit lower solubility and bioavailability. Pharmaceutical formulations face a significant challenge in improving the bioavailability and solubility of drugs. Class II and IV drugs (APIs) have poor solubility, lower bioavailability, and less dissolution, according to the Classification of Biopharmaceutics. The complexation of active molecules, the use of emulsion formation, micelles, microemulsions, cosolvents, polymeric micelle preparation, particle size reduction technologies, pharmaceutical salts, prodrugs, the solid-state alternation technique, soft gel technology, drug nanocrystals, solid dispersion methods, crystal engineering techniques, and more are just a few of the technologies discussed in this article to increase the solubility of poorly water-soluble drugs. With reference to a number of pertinent research reports, this review primarily describes a number of other cutting-edge methodologies for improving solubility and bioavailability, including crystal engineering, micronization, solid dispersions, nano sizing, the use of cyclodextrins, solid lipid nanoparticles, colloidal drug delivery systems, and drug conjugates.

Keywords: solubility; bioavailability; dissolution; nanoparticles; encapsulation; BCS classification; low water solubility; solid dispersion; crystal engineering; solid lipid nanoparticles; drug conjugates;
micronization; micelles

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Biology

Writer Experience: 20+ Years

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