Description
Title: An Understanding of Breast Cancer Brain Metastasis’ Molecular Targets
Abstract: One of the main causes of death in breast cancer (BC) patients is brain metastasis, which has a profound impact on quality of life, physical activity, and interdependence on multiple people. A precise mechanism relating to brain metastasis in BC patients is not depicted in scientific literature with any convincing evidence. Breast cancer subtypes differ in their propensity to develop breast cancer brain metastases (BCBMs), with luminal subclass (ER+ (estrogen positive) or PR+ (progesterone positive)) breast cancer having a tendency to develop BCBMs that ranges from almost half with triple-negative breast cancer (TNBC) (HER2ER PR) to one-third with HER2+ (human epidermal growth factor receptor 2-positive). This review focuses on the molecular pathways that BCBMs and their potent drugs that are being tested in various stages of clinical trials may use as therapeutic targets. The scientific community is optimistic about elucidating the underlying mechanisms of BCBMs, which will aid in developing a successful treatment regimen with a variety of molecular targets, in light of an increase in clinical trials and systemic studies.
Keywords: brain metastases; breast cancer; chemokine receptor; HER2; TNBC
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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