Description
Title: B Cells with Persistent Polyclonal B Cell Lymphocytosis are Activated by the Interaction of CD40 and CD154
Abstract: A rare condition known as persistent polyclonal B cell lymphocytosis (PPBL) is characterized by binucleated lymphocytes, an expansion of CD19+CD27+IgM+ memory B cells, and a moderate elevation of serum IgM. It is typically diagnosed in adult female smokers. Although the clinical course is typically benign, it is unknown whether PPBL may be a step in the development of a malignant proliferative disorder. In this study, we used an ideal memory B cell culture model based on the CD40-CD154 interaction to examine the functional response of B cells from patients with PPBL. We discovered that PPBL B cells proliferated at nearly the same rate as B cells from healthy controls, leading to high immunoglobulin secretion and in vitro isotypic switching. We come to the conclusion that the CD40-CD154 activation pathway is functional in the population of memory B cells in PPBL patients, indicating that the disorder may be caused by either the dysfunction of other cells in the microenvironment or a potential flaw in another B cell activation pathway.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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