Description
Title: Sickle Cell Trait and Glucose-6-Phosphate Dehydrogenase Deficiency in Potential Blood Donors: A Cross-Sectional Study in Berekum, Ghana
Abstract: Background. Patients with severe anemia frequently undergo blood transfusions as a form of treatment. Road traffic accidents, severe Plasmodium falciparum infections, haemoglobinopathies, and acute hemolysis are the main causes of severe anemia in Ghana. Method. This cross-sectional study examined blood donors at the Holy Trinity Hospital in Berekum, in the Brong-Ahafo Region of Ghana, for the presence of the sickle cell haemoglobin variant and the G6PD enzymeopathy. A questionnaire was used to collect demographic information and other relevant details. Using cellulose acetate electrophoresis, variants of sickle cell hemoglobin were discovered (pH 8.6). Methaemoglobin reduction and the Trinity Biotech G6PD test kit were used, respectively, to determine the qualitative G6PD status and the quantitative G6PD enzyme activity. Results. The combined prevalence of G6PD enzymopathy and sickle cell trait (SCT) was 7%. Additionally, 19.5% of the donors had G6PD enzyme activity between 10% and 60% of normal, indicating that recipients who receive these donor units may experience acute hemolysis brought on by stressors. Mild G6PD activity, commercial (p = 0.020, OR: 5.609, CI: 1.309-24.035), and voluntary (p = 0.034, OR: 2.404, CI: 1.071-5.397) donors were all significantly associated with SCT. Conclusion. To safeguard high-risk recipients, screening for red cell pathologies must be incorporated into current protocols for populations with a high incidence of hemoglobinopathies.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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