Description
Title: Patients with Sickle Cell Disease in Palestine: Red Blood Cell Alloimmunization Rates
Abstract: Background. Red blood cell (RBC) transfusion is a crucial therapeutic strategy for sickle cell disease (SCD). Alloimmunization from repeated RBC transfusions makes it more difficult to cross-match and find compatible blood for transfusions. This study looked into the prevalence of RBC alloimmunization among Palestinian SCD patients and associated risk factors. Materials and procedures 116 previously transfused SCD patients from three centers in the West Bank, Palestine, were the subjects of a multicenter cross-sectional study. Data on demographics, health, and transfusion history were logged. Blood samples were taken from SCD patients who had consented to blood transfusions. The identification and screening of antibodies was done using the gel card method. For the detection of autoantibodies in all patients, polyspecific (anti-IgG + C3d) anti-human globulin (AHG) gel cards were used in the autocontrol and direct antiglobulin (DAT) tests. Results. 54 (46.6%) and 62 (53.4%) of the SCD patients had sickle thalassemia (S/thal), respectively. 53 (45.7%) females and 63 (54.3%) males were present. 18.8 years old on average (range 3-53 years). Anti-K showed the highest frequency (33.3%), followed by anti-E (22.2%), anti-D (11.1%), anti-C (11.1%), and anti-c (11.1%), in terms of RBC alloimmunization frequency among SCD patients. IgG alloantibodies against antigens in the Rh (66.7%) and Kell (33.3%) systems made up all of the reported cases. The most frequent risk factors for alloimmunization in our study were older patient ages, more blood units transfused, and splenectomy. Conclusions. Although the RBC alloimmunization rate among Palestinian SCD patients is low when compared to neighboring nations and nations worldwide, it still merits more consideration. Before receiving their first transfusion, donors and recipients’ RBC should be phenotyped for K1 and Rh antigens (partial phenotypematching). This procedure can lower the incidence of alloimmunization.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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