Description
Title: Sickle Cell Anaemia and Abnormalities of Lung Function
Abstract: Background. It has been demonstrated that the majority of sickle cell disease (SCD) patients experience abnormal lung function tests even at steady state. In other populations, the prevalence and pattern of these lung function abnormalities have been described, but our sickle cell cohort has not. The risk factors linked to lung function abnormalities and their importance in patient care are generally not well understood. Method. 76 clinically stable adult Hb-SS participants who had never taken hydroxyurea participated in this analytical cross-sectional study, along with 76 controls who did not have sickle cell disease (non-SCD). The participants’ sociodemographic information and clinical history were gathered using a structured questionnaire. Spirometry, pulse oximetry, measurements of the tricuspid regurgitant jet velocity (TRV) using an echocardiogram, complete blood counts, free plasma hemoglobin, serum urea, and creatinine were among the investigations carried out. Results. The predicted values for weight, BMI, meanFVC, and FEV1% were significantly lower in the Hb-SS patients (p 0.001). The majority of Hb-SS patients who experienced abnormal spirometry results had restrictive defects (p 0.001), and there was no correlation between steady-state Hb, WBC count, free plasma hemoglobin, the frequency of sickling crises, chronic leg ulcers, or TRV measurements (p > 0.05). Patients with Hb-SS had a significantly lower mean oxygen saturation (p 0.001). Conclusion. When compared to non-SCD controls, measured lung volumes were significantly lower in Hb-SS patients, and anthropometric variance had no impact on this difference. Although restrictive defects, in particular, are common in Hb-SS patients, they did not significantly correlate with known disease severity markers.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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