Description
Title: Hematological and Clinical Implications of Haptoglobin Gene Polymorphism in West Cameroon Sickle Cell Patients
Abstract: Haptoglobin is a protein that helps the body fight off the negative effects of free hemoglobin, but because the haptoglobin gene is polymorphic, different genotypes do not have the same ability to do so. The goal of the current study was to identify the polymorphic distribution of haptoglobin in sickle cell patients (SCPs) from West Cameroon and its effects on hematological parameters and the severity of the disease’s clinical manifestations. Allele-specific polymerase chain reaction was used to determine the hemoglobin genotype of 102 SCPs (SS) and 115 healthy individuals (60 AA and 55 AS), and the AutoAnalyzer was used to determine the complete blood count. The genotype Hp2-2 was significantly more prevalent (p 0.05) in SS patients than in controls AA and AS (27% and 29%, respectively), while Hp2-1 was significantly less prevalent (15%) in SS and more prevalent (p 0.05) in AS (42%) and AA (38%). The allelic distribution in SS patients was Hp2: 0.613, Hp1S: 0.304, and Hp1F: 0.084. Hp1 and Hp2 allele frequencies were similar (around 0.5) in controls from AS and AA, with 0.282 for Hp1S and 0.218 for Hp1F in AS and 0.283 for Hp1S and 0.258 for Hp1F in AA. The distribution of haptoglobin genotypes in SCP and controls did not show any evidence of a significant difference in hematological parameters or clinical manifestations of disease severity. The SCP with the Hp1S-1F genotype had the highest hemoglobin level. Although Hp2-2 was more common in SS patients, neither the hematological parameters nor the severity of the disease seemed to be associated with it. Further research is required to examine the effects of HP polymorphism on antioxidant, lipid profile, and tissue functionality in SCP in Cameroon.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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