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Title: Analysis of 25 High-THC Cannabis Extracts’ Anti-Cancer and Anti-Inflammatory Properties
Abstract: One of the earliest cultivated plants is Cannabis sativa. Despite the fact that very few cannabis-based formulations have been approved as drugs, cannabis is known to have many medicinal properties. Previous studies have shown that the therapeutic effects of various cannabis strains vary greatly. This is most likely because of the entourage effect, which is the synergistic or antagonistic interaction between different cannabinoids and terpenes. In this study, we examined 25 cannabis extracts with high delta-9 tetrahydrocannabinol concentrations (THC). We tested the effectiveness of the extracts using HCC1806 squamous cell carcinoma, showing ranges from 66% to 92% of growth inhibition of cancer cells. TNF-/IFN- induction of inflammation in WI38 human lung fibroblasts was used to test for inflammation. The effectiveness of the extracts was evaluated by examining the expression of COX2 and IL6; while some extracts increased COX2/IL6 expression by twofold, aggravating inflammation, other extracts decreased inflammation by over fivefold reducing cytokine expression. The level of THC, CBD, CBG, and CBN, as well as 20 major terpenes, were then examined. Clustering and association analysis were then used to determine how well the extracts inhibited cancer growth and reduced inflammation. Terpinene was found to have a positive correlation with the anti-cancer property (pval = 0.002); eucalyptol was found to have a negative correlation (pval = 0.094); p-cymene and -myrcene were found to have positive correlations with the inhibition of IL6 expression; and camphor was found to have a negative correlation. For COX2, no meaningful correlation was discovered. The following pairs of cannabinoids and terpenes showed positive correlations when we conducted an analysis of their relationships: -pinene vs. CBD, p-cymene vs. CBGA, terpenolene vs. CBGA, and isopulegol vs. CBGA. Thus, our research revealed that only a small number of carefully chosen high-THC extracts exhibited anti-inflammatory activity. The presence of some terpenes, including terpinene, eucalyptol, cymene, myrcene, and camphor, seems to have an impact on how active certain cannabinoids are.
Keywords: Cannabis sativa; flower extracts; delta-9-tetrahydrocannabinol; anti-cancer property;
anti-inflammatory property
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Chemistry
Writer Experience: 20+ Years
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