Research Paper on Clarification of the Molecular Mechanisms of CVB3-Induced Viral Myocarditis and Dilated Cardiomyopathy by NMR-Based Metabolomic Analysis of Cardiac Tissues

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Title: Clarification of the Molecular Mechanisms of CVB3-Induced Viral Myocarditis and Dilated Cardiomyopathy by NMR-Based Metabolomic Analysis of Cardiac Tissues

Abstract: Viral myocarditis (VMC), which is characterized as myocardial inflammation and subsequent myocardial injury, may progress into a chronic condition that eventually results in dilated cardiomyopathy (DCM). Uncertain molecular mechanisms underlie the development of acute VMC (aVMC), chronic VMC (cVMC), and finally DCM. Here, we developed mouse models of Coxsackievirus B3-infected VMC and DCM, and we performed NMR-based metabolomic analysis of aqueous metabolites extracted from cardiac tissues of three histologically distinguished groups, including aVMC, cVMC, and DCM. We demonstrated that these three pathological groups were metabolically distinct from their normal counterparts and identified three impaired metabolic pathways that were shared by these pathological groups relative to normal controls. These pathways were D-glutamine and D-glutamate metabolism, alanine, aspartate, and glutamate metabolism, and nicotinate and nicotinamide metabolism. Additionally, we found two additional impaired metabolic pathways in the aVMC group, including taurine and hypotaurine metabolism and glycine, serine, and threonine metabolism. Additionally, we discovered potential cardiac biomarkers that could be used to metabolically separate these three pathological stages from healthy controls. Our findings suggest that the molecular mechanisms underlying the transition from acute VMC to DCM can be better understood by performing a metabolomic analysis of cardiac tissues.

Keywords: viral myocarditis; dilated cardiomyopathy; metabolomics; NMR; cardiac tissue

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Chemistry

Writer Experience: 20+ Years

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