Description
Title: Tricalcium Phosphate Ceramics with Strontium Substitutes: Physiochemical Characteristics and Cytocompatibility
Abstract: The mechano-chemical activation method was used to synthesize Sr2+-substituted tricalcium phosphate (-TCP) powders, which were then pressed and sintered to produce ceramics. With the anticipated Ca3(PO4)2, Ca2.9Sr0.1(PO4)2, and Ca2.5Sr0.5(PO4)2 formulas, respectively, the concentration of Sr2+ in the samples was 0 (non-substituted TCP, as a reference), 3.33 (0.1SrTCP), and 16.67 (0.5SrTCP) mol.%. Energy-dispersive X-ray spectrometry (EDX) and inductively coupled plasma optical emission spectroscopy (ICP-OES) techniques were used to confirm the chemical compositions. Apatite (Ap)-type phase was more prevalent in 0.1SrTCP than in the other compounds when the phase composition of the synthesized powders and ceramics was studied using the powder X-ray diffraction (PXRD) method. TCP and 0.5SrTCP ceramics were soaked in the standard saline solution for 21 days, and the phase analysis showed that the Ap-type phase and changes in the ceramics’ microstructure caused a partial dissolution of the initial -TCP phase. The ICP-OES was used to measure the Sr2+ ion release from the ceramic. Studies on viability, adhesion, spreading, and cytocompatibility used the human osteosarcoma MG-63 cell line. The findings demonstrate that the prepared samples’ cell adhesion, proliferation, and cytocompatibility were all enhanced by the addition of Sr2+ ions to the -TCP. The obtained results serve as a foundation for using the Sr2+-substituted ceramics in model in vivo experiments.
Keywords: ceramic; strontium; tricalcium phosphate; strontium substituted tricalcium phosphate; strontium doped tricalcium phosphate; dissolution; cells adhesion; cytocompatibility
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Chemistry
Writer Experience: 20+ Years
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