Description
Title: Flupyrimin-Based Novel Low Bee-Toxicity Compounds: Design, Synthesis, and Bioactivity
Abstract: Neonicotinoids are crucial insecticides for reducing aphid populations in agricultural settings. Neonicotinoid insecticides may be a major contributor to the decline of bees and other global pollinator insects, according to growing research. A brand-new nicotinic insecticide with distinct biological characteristics, no cross-resistance, and no danger to pollinators is called flupyrimin (FLP). By substituting a sulfonamideone for the amide fragment in FLP, a series of novel compounds were created and synthesized. The 1H NMR, 13C NMR, and HRMS spectra were used to confirm their structures. With an LC50 value of 20.93 mg/L, the bioassay results demonstrated that compound 2j had good insecticidal activity against Aphis glycines. Comparatively less acute oral and contact toxicity was observed for Apis mellifera with compound 2j. Additionally, compound 2j worked well with the insect acetylcholine binding protein protein (AChBP). The sulfonamide group of compound 2j did not form a hydrogen bond with Arg173 of the subunit, which conforms to the reported low bee-toxicity conformation, according to molecular docking on honeybee nicotinic acetylcholine receptor (nAChR). Target compound 2j is a candidate for an insecticide that is bee-friendly in general.
Keywords: low bee-toxicity; nicotinic insecticide; nicotinic acetylcholine receptor (nAChR); Flupyrimin derivatives; molecular docking
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Chemistry
Writer Experience: 20+ Years
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