Description
Title: Benzimidazole-Based Thiazole Derivatives: Synthesis, Biological Analysis, and Molecular Docking Study of Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease
Abstract: The potential to inhibit butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE) in vitro was examined for 24 analogues of benzimidazole-based thiazoles (1-24). As compared to the industry standard drug Donepezil (IC50 = 2.16 0.12 and 4.5 0.11 M, respectively), all analogues were found to exhibit good inhibitory potential against cholinesterase enzymes. Their IC50 values ranged from 0.10, 0.05 to 11.10 0.30 M (for AChE) and 0.20, 0.050 M to 14.20 0.10 M (for BuChE). Analogues 16 and 21 from the series were discovered to be the most powerful inhibitors of the AChE and BuChE enzymes. The main factors influencing the structure-activity relationship were the number (s), types, electron-donating or -withdrawing effects, and position of the substituent(s) on both phenyl rings B & C. (SAR). Molecular docking studies were carried out to investigate the interactions of the most active derivatives with the amino acids in the active site of the enzyme. The outcomes confirmed the findings of the experiment. All newly synthesized compounds’ structures were also clarified using a variety of spectroscopic techniques, including 13C-NMR, 1H-NMR, and HR EIMS.
Keywords: Synthesis; acetylcholinesterase; butyrylcholinesterase; benzimidazole; thiazole; structureactivity relationship; molecular docking
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Chemistry
Writer Experience: 20+ Years
Plagiarism Report: Turnitin Plagiarism Report will be less than 10%
Restriction: Only one author may purchase a single paper. The paper will then indicate that it is out of stock.
What will I get after the purchase?
A turnitin plagiarism report of less than 10% in a pdf file and a full research paper in a word document.
In case you have any questions related to this research paper, please feel free to call/ WhatsApp on +919726999915
Reviews
There are no reviews yet.