Description
Title: Streptococcus mutans Biofilms and Dental Caries-Related Virulence Phenotypes are Inhibited by Baicalein
Abstract: The most prevalent oral disease, dental caries, affects more than three billion people worldwide and is a significant public health burden. Today’s understanding of the importance of a balanced microbiome and the rise of antimicrobial resistance have made it urgent to find substances that can reduce pathobiont virulence without microbial killing. The 5,6,7-trihydroxyflavone (Baicalein) significantly downregulates critical caries-related virulence phenotypes in Streptococcus mutans, as we have shown for the first time in this study. Without significantly affecting growth, baicalein significantly reduced the ability of Streptococcus mutans UA159 to form biofilms (MBIC50 = 200 M). Notably, the commensal S. gordonii was unaffected by these baicalein concentrations. Surprisingly, baicalein significantly decreased the acid production, autoaggregation, and hydrophobicity of S. mutans cell surfaces. Numerous genes controlling biofilm formation, surface attachment, quorum sensing, acid production, and competence were downregulated, according to mechanistic studies (qRT-PCR). Finally, by reporting a synergistic interaction between fluoride and baicalein against S. mutans biofilms, we show the potential translational value of baicalein.
Keywords: baicalein; biofilm; dental caries; hydrophobicity; hydroxyflavone; Streptococcus mutans
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Antibiotics
Writer Experience: 20+ Years
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