Research Paper on By focusing on its carbapenemases and the AcrAB-TolC Efflux System, the Galactose-Clicked Curcumin-Mediated Reversal of Meropenem Resistance in Klebsiella pneumoniae reverses this resistance.

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Title: By focusing on its carbapenemases and the AcrAB-TolC Efflux System, the Galactose-Clicked Curcumin-Mediated Reversal of Meropenem Resistance in Klebsiella pneumoniae reverses this resistance.

Abstract: Despite the discovery of new antibiotics over the past 80 years, the rapid emergence of multidrug resistance among bacterial pathogens has shaken our perception of our ability to successfully combat them. More quickly than new antibiotics and antimicrobials are being discovered, resistance is increasing. It makes sense to look for better antimicrobials and additives as a result. Utilizing a Cu (I) catalyzed 1, 3-cyclo addition reaction, a water-soluble curcumin derivative (Curaq) was created. It has been tested as a potential antibiotic adjuvant for meropenem against hypervirulent multidrug-resistant Klebsiella pneumoniae isolates and as a potential treatment for isolates that are multidrug resistant. Additionally, we looked into its solubility and impact on carbapenemase activity. We also looked into how it affected the AcrAB-TolC system. At a minimum concentration of 16 g/mL, Curaq was found to inhibit bacterial growth; at a 32 g/mL concentration, it completely stopped bacterial growth. Meropenem was only sensitive to nine (9.4%) Klebsiella isolates, but 85 (88.54%) hvKP isolates became sensitive to the medication when it synergized with Curaq (8 g/mL). At a concentration of 1 g/mL, the Curaq also prevented the AcrAB-TolC efflux system from working by depolarizing the membrane potential. The kinetic parameters discovered also showed promise for its ability to inhibit carbapenemase. According to these findings, Curaq may make a great candidate for a broad-spectrum antibacterial and anti-efflux drug.

Keywords: bliss modelling; synergism; AcrAB-TolC; bla_KPC; mCIM; eCIM

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Antibiotics

Writer Experience: 20+ Years

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