Research Paper on Ibrexafungerp is a brand-new oral triterpenoid antifungal that is being developed to treat infections caused by the Candida auris fungus.

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Title: Ibrexafungerp is a brand-new oral triterpenoid antifungal that is being developed to treat infections caused by the Candida auris fungus.

Abstract: A new, globally reported multidrug-resistant fungal pathogen is Candida auris. Nosocomial infections caused by C. auris are frequently fatal and have high rates of fluconazole resistance. The first-line of treatment is echinocandins. Echinocandins, on the other hand, are only available intravenously and are connected to rising levels of C. auris resistance. Therefore, there is a need for cutting-edge drugs that have strong anti-C. auris activity. A revolutionary triterpenoid antifungal agent is ibrexafungerp. Ibrexafungerp inhibits (13)-D-glucan synthase, a crucial component of the fungal cell wall, similarly to echinocandins and has fungicidal activity against Candida spp. Ibrexafungerp exhibits broad anti-Candida spp. in vitro activity, including C. auris and C. auris isolates with fks mutations. More than 400 C. auris isolates had minimum inhibitory concentrations (MIC50 and MIC90) of 0.5 g/mL and 1.0 g/mL, respectively. Two patients treated in the ongoing open-label CARES (Candidiasis Caused by Candida Auris) trial for invasive candidiasis or candidemia were given clinical updates. Ibrexafungerp treatment resulted in a full recovery for these patients. Ibrexafungerp is a promising new antifungal medication for the treatment of C. auris infections as a result.

Keywords: antifungal; ibrexafungerp; Candida auris; resistance

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Antibiotics

Writer Experience: 20+ Years

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