Description
Title: Influence of SNPs on the Pharmacokinetics of Rifampin in Patients with Tuberculosis
Abstract: The active metabolite of rifampin (RF), 25-desacetylrifampin, is formed in the liver and is excreted almost equally through the biliary and renal systems. The disposition of RF during hepatic absorption and biliary excretion is influenced by a variety of influx and efflux transporters. Additionally, research has demonstrated a link between tuberculosis and variations in the vitamin D receptor (VDR) and vitamin D deficiency (VDD) (TB). Therefore, the pharmacokinetics of RF may be impacted by genetic polymorphisms in drug transporters, metabolizing enzymes, and/or their transcriptional regulators, as well as VDR and its pathway regulators. The purpose of this narrative review is to locate research that has examined the impact of single nucleotide polymorphisms (SNPs) in the genes encoding drug transporters and their transcriptional regulators (SLCO1B1, ABCB1, PXR, and CAR), metabolizing enzymes (CES1, CES2, and AADAC), and VDR and its pathway regulators (VDR, CYP27B1, and CYP24A1) on plasma RF concentrations in The information currently available indicates that there is no correlation between the genetic variations ABCB1, PXR, CAR, CES1 and AADAC and plasma concentrations of RF. To reach definitive conclusions, additional evidence from a more thorough investigation of the relationship between RF pharmacokinetics and gene variants in the SLCO1B1, CES2, and Vitamin D pathway in different ethnic groups and a larger population is needed.
Keywords: tuberculosis; rifampin; single nucleotide polymorphisms; SLCO1B1; pharmacokinetics
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Antibiotics
Writer Experience: 20+ Years
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