Research Paper on Quercetin and magnesium-doped calcium silicate’s simultaneous effects on scaffolds for bone regeneration’s osteogenic and antibacterial activity

Description

Title: Quercetin and magnesium-doped calcium silicate’s simultaneous effects on scaffolds for bone regeneration’s osteogenic and antibacterial activity

Abstract: A bioflavonoid with a wide range of biological activity is quercetin. It is typically encapsulated or a metal-quercetin complex is formed to enhance its biological activity at a lower concentration due to its lower chemical stability. Here, we took a novel approach to take advantage of the antibacterial activity of quercetin within the antibacterial and osteogenic potential of the calcium silicate (CMS) by coprecipitating a quercetin complex to CMS ceramics. Because quercetin naturally chelates metals, the concentration of Ca+Mg/Si increased. Regarding quercetin concentration, quercetin in magnesium-doped calcium silicate ceramic  demonstrated concentration-dependent pro-oxidant and antioxidant activity in SaOS-2. In comparison to the polycaprolactone/polyvinylpyrrolidone (PCL/PVP) scaffold, we were able to maximize the relative concentration and achieve 3-fold higher proliferation, 1.6-fold higher total collageand a 1.7-fold higher alkaline phosphatase production at day 7. S. aureus and other Gram-positive bacteria are resistant to quercetin. When combined with CMS, quercetin has a similar effect at a lower quercetin concentration than when taken alone. Bacterial adhesion, proliferation, and biofilm formation were all inhibited by quercetin. As a result, calcium silicate doped with magnesium and coupled with quercetin increased osteogenic potential while also decreasing bacterial adhesion. and expansion.

Keywords: quercetin; magnesium-doped calcium silicate; osteogenic activity; ntibacterial activity; bone regeneration and nanofiber scaffold

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Antibiotics

Writer Experience: 20+ Years

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