Description
Title: Black Bengal Goats in West Bengal, India: Antimicrobial Resistance Pattern, Clustering Mechanisms, and Correlation Matrix of Drug-Resistant Escherichia coli
Abstract: To understand the risk factors, antimicrobial resistance mechanism, and clustering of the resistance characteristics of Escherichia coli isolated from healthy (170) and diarrhoeic (74) goats reared under intensive (52) and semi-intensive (192) farming practices, a cross-sectional study covering four agro-climatic zones of West Bengal, India, was conducted. The majority of the 488 E. coli isolates, including those that produced the AmpC -lactamase (ACBL) (n = 86, 17.62%) and the extended spectrum (n = 64, 13.11%), were resistant to tetracycline (25.2%), enrofloxacin (24.5%), cefotaxime (21.5%), and amikacin (20.5%). The isolates from diarrheal animals (p 0.001) are probably more likely to be ACBL-positive than their healthy counterparts, according to statistical modeling. Similar to this, intensively reared goats and goats with diarrhea had significantly higher levels of cefotaxime (p 0.05) and enrofloxacin (p 0.01) resistance. The isolates (n = 35) with multiple drug resistance showed the presence of -lactamase [blaCTXM-1-(21), blaSHV-(7), blaTEM-(3), blaCMY-6-(1), blaCITM-(3)], quinolone [qnrB-(10), qnrS-(7), aac(6′)-Ib-cr-(3)], tetracycline [tetA-(19 Furthermore, eight isolates were powerful biofilm producers, and two isolates carried the carbapenem resistance gene (blaNDM-5). This pioneering study, which sought to understand the status of AMR in goat farming, found that clinical conditions like diarrhea, in addition to intensive farming methods, can increase the shedding of drug-resistant isolates. Concerningly, the emergence of multi-drug resistant (MDR) E. coli in goats, particularly those that are carbapenem resistant, shows that such pathogens can spread even in the livestock sub-sector, which is typically viewed as naive.
Keywords: acrAB; AMR; carbapenem; diarrhoea; ESBL; farming practice; goat
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Antibiotics
Writer Experience: 20+ Years
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