Description
Title: New medications in the acute obturating pulmonary disease
Abstract: Inhaled bronchodilators, such as b2-agonists and muscarinic antagonists, reduce the frequency and severity of exacerbations, improve health status and exercise tolerance, and have a favorable safety profile. They also aid in the prevention and control of symptoms in COPD patients. Combining bronchodilators from various classes, such as long-acting b2-agonists or long-acting muscarinic antagonists (LABA/LAMA), is advised for patients with moderate to severe COPD. The first LABA with a once-daily dosage is indacaterol, which has a 24 hour duration and a rapid onset of bronchodilation. Utilizing indacaterol alone or in conjunction with LAMA may be advantageous due to the ease of use and increased efficacy of the medication. As the patient’s COPD worsens and they experience frequent exacerbations, triple therapy with LABA/LAMA/ICS may be necessary. In patients with severe COPD, adding a PDE4 inhibitor (roflumilast) to LABA or LAMA improves lung function and lowers the frequency of exacerbations. Similar decreases in exacerbation frequency have been observed in studies using bronchodilators and inhaled corticosteroid therapy. PDE4 inhibitors have been demonstrated to have a role in the treatment of severe COPD, and they work best when combined with other pharmaceuticals. According to study findings, combining different drug classes appears to be a critical step in helping COPD patients achieve optimal control.
Keywords: COPD, LABA, LAMA, ICS, PDE4 inhibitors
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Advances in Respiratory Medicine
Writer Experience: 20+ Years
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