Description
Title: Recent developments in certain molecular events in the sarcoidosis pathogenesis
Abstract: The lungs and lymph nodes are most frequently affected by sarcoidosis, an orphan inflammatory disorder that can affect virtually any organ or system in the body. It is thought that sarcoidosis results from the interaction of genetic and environmental factors. Numerous studies highlight a strong correlation between specific human leukocyte antigen (HLA) alleles and susceptibility to sarcoidosis. The further assessment of additional candidate genes with a potential role in the immunopathogenesis of sarcoidosis has been made possible by a number of new insights. This review provides an overview of recent developments in the discovery of novel molecular markers that may be relevant to various disease stages, including the acute phase of inflammation, granuloma formation, and fibrosis. This article also clarifies how the TGF-b/Smad and (HIF)-1a-VEGF-ING-4 signaling pathways contribute to the emergence of sarcoidosis. Also discussed is the idea that miRNA may function as an epigenetic regulator of the sarcoidosis-related processes.
Keywords: sarcoidosis, molecular markers, pathogenesis
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Advances in Respiratory Medicine
Writer Experience: 20+ Years
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