Description
Title: Pancreatic Cancer Metastasis: Epigenetic Changes
Abstract: The third most common cancer-related cause of death in the US is pancreatic cancer. The most prevalent (90%) and aggressive form of pancreatic cancer is pancreatic ductal adenocarcinoma (PDA). Genetic mutations that frequently drive the initiation and progression of PDA have been discovered through genomic analyses of PDA specimens. The underlying mechanisms that further fuel PDA metastasis are still unknown, though. Despite numerous attempts, no recurrent genetic mutation that causes PDA metastasis has been identified, indicating that epigenetic fluctuations rather than genetic factors are what cause PDA metastasis. Therefore, identifying the epigenetic mechanisms underlying PDA metastasis would make it easier to create effective therapeutic approaches. In this review, we give a thorough overview of how epigenetic mechanisms play a key role in the development and metastasis of PDA. We focus on recent discoveries that help explain how DNA methylation, histone modification, and nucleosome remodeling play a part in the metastasis of cancer.
Keywords: pancreatic cancer; epigenetics; metastasis; DNA methylation
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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