Description
Title: Treatment of Glaucoma Using Cell-Based Therapies for Trabecular Meshwork Regeneration
Abstract: If left untreated, glaucoma causes damage to the retinal ganglion cells (RGC), optic nerve, and eventually blindness. Glaucoma is clinically characterized by elevated intraocular pressure (IOP). The only way to effectively prevent blindness, even in people with normal pressure glaucoma, is currently to lower IOP by either increasing aqueous humor outflow or decreasing aqueous humor production. By offering resistance when aqueous humor drains through the tissue, the trabecular meshwork (TM) and the nearby Schlemm’s canal inner wall play a crucial part in controlling IOP. The reduced cellularity, abnormal extracellular matrix accumulation, and increased stiffness of the TM tissue seen in glaucoma contribute to the elevated IOP, but current treatments do not target the TM tissue. As a more direct and efficient treatment for glaucoma, stem cell transplantation for regeneration and re-functionalization of damaged TM has shown promise. We discuss the mechanisms of regeneration, the use of various stem cell types for TM regeneration in glaucoma models, and the potential for glaucoma treatment using autologous stem cell transplantation in this review.
Keywords: glaucoma; trabecular meshwork; stem cells; regeneration; intraocular pressure
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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