Description
Title: 12-Lipoxygenases Control Tissue Inflammation
Abstract: The lipid-metabolizing enzymes known as lipoxygenases (LOXs) catalyze the di-oxygenation of polyunsaturated fatty acids to produce active eicosanoids. Twelve-carbon substrates are primarily oxygenated by 12-lipoxygenases (12-LOXs). Numerous studies have shown the important pathological effects of 12-LOXs and the eicosanoid metabolite 12-hydroxyeicosatetraenoate (12-HETE) on inflammatory diseases. Increased 12-LOX activity encourages stress-mediated inflammation that is mediated by endoplasmic reticulum and oxidative stress, which causes damage to these tissues. Additionally, 12-LOXs are linked to increased immune cell migration, which is a symptom of several autoimmune and metabolic diseases. In animal models of diabetes, pulmonary, cardiovascular, and metabolic disease, genetic depletion or pharmacological inhibition of the enzyme has been shown to be protective against disease development and/or progression, indicating a translational potential of targeting the enzyme for the treatment of several disorders. In this article, we discuss the part 12-LOXs play in the pathogenesis of a number of illnesses where chronic inflammation is a contributing factor.
Keywords: 12-lipoxygenases; 12-LOXs; 12/15-lipoxygenase; 12/15-LOX; lipoxygenases; eicosanoids; inflammation
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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