Description
Title: Molecular Targets for the Relief of Cancer Pain: TRP Channels
Abstract: Critical receptors in the transmission of nociceptive stimuli are transient receptor potential (TRP) channels. Growth factors, neurotransmitters, and inflammatory mediators, among other substances, are released into the microenvironment of various cancer types, and these substances modify the activity of TRPs by controlling intracellular signaling pathways. Mildly noxious sensory stimuli are perceived as causing hyperalgesia and allodynia in cancer patients due to the modulation of TRP channels, which is linked to peripheral sensitization. Plant extract-derived secondary metabolites have the ability to activate, block, and desensitize TRP channels. These substances may therefore have therapeutic potential because they have antinociceptive properties that could help with cancer-related pain relief. We will discuss molecules that have been reported to modulate these channels in this review, as well as the role of TRPV1 and TRPA1 in cancer-related pain. We will pay particular attention to the mechanisms of channel activation linked to molecules released in the tumor microenvironment.
Keywords: cancer; pain; TRP channels
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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