Description
Title: The Function of Epigenetic Alterations in the Pathogenesis of Abdominal Aortic Aneurysms
Abstract: In the event of an acute rupture, abdominal aortic aneurysm (AAA) is a condition that can be fatal and is associated with high morbidity and mortality rates. Recently, improvements in the surgical and endovascular treatment of AAA have been made, but there are still no pharmaceutical therapies to stop AAA expansion and rupture. This emphasizes the ongoing need to enhance our understanding of the pathological mechanisms that start AAA off, support its growth, and encourage rupture. Epigenetic modifications like DNA methylation, posttranslational histone modifications, and non-coding RNA have become recognized as significant regulators of cellular function in the last ten years. The importance of epigenetic enzymes in the dynamic regulation of important signaling pathways that change cellular phenotypes and have emerged as key intracellular players in a wide range of biological processes is becoming increasingly clear as studies mount. The roles and ramifications of epigenetic modifications in AAA animal models and their relevance to human AAA pathology are discussed in this review.
Keywords: macrophage; monocyte; inflammation; epigenetics; cardiometabolic; vascular
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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