Description
Title: Cardiovascular Diseases and Cullin-RING Ubiquitin Ligases
Abstract: Almost every aspect of eukaryotic biology depends on maintaining protein homeostasis. The ubiquitin-proteasome system (UPS) is a tightly controlled quality control system that shields cells from various stressors and noxious proteins. The pathogenesis of cardiovascular diseases is influenced by UPS dysfunction, according to a large body of evidence. The cullin-RING ubiquitin ligases (CRLs), a crucial component of the UPS, play both physiological and pathological roles in the cardiovascular system, and this review highlights the most recent research in this area. The factors controlling CRL activities are also discussed in order to stimulate future therapeutic discovery.
Keywords: ubiquitin E3 ligases; cullin-RING ligases; protein ubiquitination; protein degradation; cardiovascular disease
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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