Description
Title: Understanding the Role of PARP1 in DNA Methylation Malleability and Dysregulation in Cancer Progression
Abstract: Mammalian genomic DNA methylation is a significant epigenetic modification, and it is dynamically regulated to regulate the expression of numerous developmental pathways. In particular, the mitotic inheritance of gene expression patterns makes it the primary governing mechanism of epigenetic change to the subsequent generation of cells. It maintains the gene expression of one generation of cells. Recent research has provided compelling evidence that TET dioxygenase, an enzyme that oxidizes the methyl group of cytosine and activates transcription, is responsible for the dynamic regulation of DNA methylation. Genes are improperly activated or inhibited in the incorrect cellular context as a result of aberrant DNA modifications, which contributes to a variety of inheritable diseases, including cancer. In this article, we discuss recent developments in our knowledge of how DNA alterations affect the activation of oncogenic genes, the silencing of tumor suppressor genes, and the dysregulation of DNA methylation in the development of cancer. We also highlight the role that PARP1 enzymatic activity or inhibition plays in the upkeep of DNA methylation dysregulation. The significance of DNA methylation and PARP1 pharmacological inhibitors as a combination therapy is emphasized in the context of cancer treatment.
Keywords: DNA demethylases; DNA demethylases inhibitors; PARP1; poly(ADP-ribose); DNA methylation; tumor suppressor gene; oncogene; tumor progression; cancer cells
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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