Description
Title: Modern Therapeutic Approaches to Target Wild-Type and Mutant P53 in Cancer
Abstract: TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding transcription factor that is activated by stressful stimuli. It upregulates target genes involved in metabolism, DNA repair, growth inhibition, cell death, and other processes. The most frequently mutated gene in tumors is TP53, and mutations not only cause loss-of-function (LOF), but also gain-of-function (GOF), which encourages metastasis and tumor progression. Mutant p53 protein has a tumor-specific status, which suggests it is a promising target for cancer treatment. We provide an overview of the state of the art in targeting wild-type and mutant p53 for cancer therapy, including biotherapeutic and biopharmaceutical approaches for (1) increasing p53 activity in cancer, (2) p53-dependent and p53-independent strategies for targeting p53 pathway functional restoration in p53-mutated cancer, (3) targeting p53 in immunotherapy, and (4) combination therapies targeting p53, p53 checkpoints, or mutant p53.
Keywords: P53; mutant p53; targeting therapy; immunotherapy; cancer
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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